一、团队简介
南通大学生物工程材料与传感研究团队聚焦阿尔茨海默病等神经退行性疾病，围绕β-淀粉样蛋白聚集调控，发展靶向分子设计、仿生纳米材料及跨血脑屏障递送技术，构建微环境响应治疗体系与治疗性细胞外囊泡平台，并融合单分子成像与数字分析，实现疾病早期诊断与精准干预。主要研究方向：
（1）治疗性细胞外囊泡开发；（2）阿尔茨海默病智能药物递送系统；（3）单分子成像与数字分析；（4）超灵敏生物标志物检测
二、团队负责人简介
马蒙蒙，博士，教授、博士生导师。2020年获中国科学技术大学理学博士学位，2022–2026年在新加坡南洋理工大学化学化工与生物工程学院从事博士后研究，入选2025年度江苏特聘教授。主要聚焦阿尔茨海默病等神经退行性疾病，围绕β-淀粉样蛋白的聚集调控、靶向药物设计及其生物学效应开展系统研究，在跨血脑屏障多功能Aβ抑制剂构建、刺激响应型药物释放体系及治疗性细胞外囊泡开发等方面取得系列进展。近五年以第一作者或通讯作者在Angew. Chem. Int. Ed.、J. Am. Chem. Soc.、Biomaterials、ACS Nano 等期刊发表SCI论文20余篇。相关成果被 Nat. Rev. Bioeng.、Acc. Chem. Res.、Chem. Soc. Rev.、Brain-X 等权威期刊作为研究亮点进行专题报道，并受到 Nanoer、X-MOL、科学网等学术媒体关注。此外，受邀担任 J. Am. Chem. Soc.、Biomaterials、ACS Appl. Nano Mater. 等国际期刊审稿人。
三、团队主要成员
肖依，博士，讲师，南通大学高层次引进人才。2021年获中国科学技术大学理学博士学位，2022–2026年在新加坡南洋理工大学数字分子分析与科学中心从事博士后研究。主要聚焦新型光学成像与单分子分析方法，在复杂体系中低丰度分子的超灵敏检测与微纳尺度过程解析方面取得重要进展。已发表SCI论文12篇，其中第一作者/通讯作者6篇，成果发表于Proc. Natl. Acad. Sci. U. S. A.、Chem、J. Am. Chem. Soc.、Nano Lett.、J. Phys. Chem. Lett.、Acta Biomaterialia等期刊。相关研究被Nat. Rev. Mater.、Annu. Rev. Anal. Chem.、Nano-Micro Lett.、Nano Energy等权威期刊作为亮点评述，并担任ACS Catal.、ACS Appl. Nano Mater.等期刊审稿人。
四、科研项目
江苏特聘教授项目（2025-2028）
五、近年代表性论文：
1. Ma, Mengmeng; Wang, Jing; Zhong, Wenbin; Li, Zhenhua; Zhao, Yanli; Cleavable Antibody-Conjugated Aβ Specific Immune Exosome for Combination Alzheimer's Disease Immunotherapy, Angewandte Chemie-international Edition, 2025, 137(47): e202517917.
2. Ma, Mengmeng; Wang, Jing; Guo, Kaiming; Zhong, Wenbin; Cheng, Yu; Lin, Li; Zhao, Yanli; A self-reinforced “microglia energy modulator” for synergistic amyloid-β clearance in Alzheimer’s disease model, Angewandte Chemie-International Edition, 2025, 64: e202420547.
3. Ma, Mengmeng; Zhao, Yanli; Protein-Taggable Near-Infrared Photocages for Theranostics of Alzheimer’s Disease, ACS Central Science, 2025, 11, 7, 1024–1025.
4. Ma, Mengmeng; Yuan, Wei; Zhong, Wenbin; Cheng, Yu; Yao, Haochen; Zhao, Yanli; In-situ activation of biomimetic single-site bioorthogonal nanozyme for tumor-specific combination therapy, Biomaterials, 2025, 312: 122755.
5. Xiao, Yi; Wong, Jia Hui; Gao, Nan; Barron, Anna M.; Stanley, Chelsea Violita; Than, Aung; Zheng, Lewen; Ling, Tong; Li, Dong-sheng; Chen, Peng; Universal artificial urinary biomarker probe enabled by aptamer-DNAzyme-nanozyme construct, Nano Letters, 2025, 25(28): 11106-11115.
6. Ma, Mengmeng; Liu, Zhenqi; Zhao, Huisi; Zhang, Haochen; Ren, Jinsong; Qu, Xiaogang; Polyoxometalates: metallodrug agents for combating amyloid aggregation, National Science Review, 2024, 11: nwae226.
7. Xiao, Yi; Guo, Zhichao; Cao, Jing; Song, Ping; Yang, Bo; Xu, Weilin; Revealing operando surface defect-dependent electrocatalytic performance of Pt at sub-particle level, Proceedings of the National Academy of Sciences of the United States of America, 2024, 121(22): e2317205121.
8. Xiao, Yi; Xu, Weilin; Single-molecule fluorescence imaging for probing nanocatalytic process, Chem, 2023, 9: 16–28.
9. Ma, Mengmeng; Wang, Jing; Jiang, Hao; Chen, Qiushui; Xiao, Yi; Yang, Huanghao; Li, Lin; Transcranial deep-tissue phototherapy for Alzheimer's disease using low-dose x-ray-activated long-afterglow scintillators, Acta Biomaterialia, 2023, 155: 635–643.
10. Ma, Mengmeng; Liu, Zhenqi; Gao, Nan; Dong, Kai; Pi, Zifeng; Kang, Lihua; Du, Xiubo; Ren, Jinsong; Qu, Xiaogang; Near-infrared target enhanced peripheral clearance of amyloid-β in Alzheimer's disease model, Biomaterials, 2021, 276: 121065.
11. Ma, Mengmeng; Liu, Zhenqi; Gao, Nan; Pi, Zifeng; Du, Xiubo; Ren, Jinsong; Qu, Xiaogang; Self-protecting biomimetic nanozyme for selective and synergistic clearance of peripheral amyloid-β in an Alzheimer’s disease model, Journal of the American Chemical Society, 2020, 142: 21702–21711.
12. Xiao, Yi; Hong, Jaeyoung; Wang, Xiao; Chen, Tao; Hyeon, Taeghwan; Xu, Weilin; Revealing kinetics of two-electron oxygen reduction reaction at single-molecule level, Journal of the American Chemical Society, 2020, 142(30): 13201–13209.
13. Ma, Mengmeng; Gao, Nan; Liu, Zhenqi; Li, Xuexia; Pi, Zifeng; Du, Xiubo; Ren, Jinsong; Qu, Xiaogang; A biocompatible second near-infrared nanozyme for spatiotemporal and non-invasive attenuation of amyloid deposition through scalp and skull, ACS Nano, 2020, 14: 9894–9903.
14. Liu, Zhenqi; Ma, Mengmeng; Yu, Dongqin; Ren, Jinsong; Qu, Xiaogang; Target-driven supramolecular self-assembly for selective amyloid-β photooxygenation against Alzheimer's disease, Chemical Science, 2020, 11: 11003–11008.
15. Xiao, Yi; Su, Yi; Liu, Xiaodong; Xu, Weilin; Defect-driven heterogeneous electron transfer between an individual graphene sheet and electrode, The Journal of Physical Chemistry Letters, 2019, 10(18): 5402–5407.
六、联系方式
Email: mmm@ntu.edu.cn
实验办公地址：南通大学啬园校区生命科学组团17号楼B106-108
欢迎感兴趣的青年人才和同学加入合作共赢！
